Do you have a chronic health problem such as asthma, diabetes or arthritis? In the US, 125 million people (around 38% of the population) suffer from these types of diseases, and treating them takes up 78% of the healthcare budget. The figures are probably similar for other developed countries.
At the Faraday Institute summer course last month, the Oxford-based biologist Paul Fairchild explained that a significant proportion of chronic diseases could be treated by replacing just one of the patient’s cell types or tissues. The use of ‘stem cells’ is a rapidly growing area of research and medicine, but it also throws up some very significant ethical issues. Continue reading →
Nearly the whole of my research career took place in the present ‘golden age’ for the study of DNA, genes and genomes. At the end of the 1960s scientists had indicated how useful it would be to be able to isolate individual genes in order to study their structure and function. That wish was fulfilled in the spin-offs from the invention in the early 1970s, of genetic modification (genetic engineering), a scientific milestone that marked the start of this golden age.
By the end of the 20thcentury experiments were being done, that thirty years earlier were not even dreamed of. This was certainly true in my research group’s work on the biochemistry and genetics of DNA replication, giving us the real privilege of uncovering some of the beautifully complex and intricate mechanisms used by cells in ‘managing’ and copying their genetic material. Continue reading →