The Problem of Pain: Brain imaging and religion

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Cortical neuron By GerryShaw (Own work) [CC BY-SA 3.0], via Wikimedia Commons
From sea slugs to humans, pain is one of the living world’s oldest and most shared experiences. Pain keeps us alive, and helps us avoid further hurt. To understand another person’s pain we have to make a guess based on what we can see, and our own experiences of being hurt. Is this child making a fuss or has he actually broken his leg? How do I react when my friend doubles up after dinner? Even our own feelings of pain are influenced by our culture and upbringing. When I have acute pain in my abdomen should I visit the doctor, take a tablet, or have a cup of tea?

Last Friday, Professor Irene Tracey, spoke at the Faraday Institute about Imaging States in Pain and Religion. Tracey is the Nuffield Professor of Anaesthetic Science at Oxford University. She also heads up the Pain Analgesia-Anaesthesia Imaging Neuroscience (P.A.I.N) Group in the department of Clinical Neurosciences, where the focus is on understanding what is happening in the brain when we feel pain.

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Human brain illustrated with millions of small nerves by Ars Electronica – Flickr. (CC BY-NC-ND 2.0)

Tracey explained that our perception of pain is a combination of prior expectation plus actual sensation. This system is efficient for our brains, because it results in a quick assessment and reaction, but it can have its disadvantages. She told a story of a builder who felt excruciating pain when a nail penetrated his boot. When he arrived at hospital and his boot was cut off, it turned out that the nail had passed between his toes.

The advantages of our pain-perception systems far outweigh the disadvantages, as any parent knows. Distraction is a wonderful way to help a child endure an injection, a grazed knee, or even something more serious. The pain modulation system is regulated through the brainstem, in response to signals from other parts of the brain. So when Mum tells Johnny it will just be a little stinging feeling, Dad kisses that knee better, or you go into work with a sprained ankle and forget all about it, the body is releasing strong pain-relief in the form of natural opioids.

Until recently, medical researchers used to publish articles about how to maximise what we now call the placebo effect. If someone is told they have been given a great drug, they are likely to feel a bit better. Doctors also knew the importance of having a good relationship with their patients as long ago as Hippocrates. Since the 1950’s, however, placebos have been thrown out of medicine. But has the baby been thrown out with the bathwater?

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Temazepam 10mg tablets-1 By Adam from UK [CC BY 2.0], via Wikimedia Commons
Tracey’s research has shown that telling a patient they are receiving a drug decreases their pain, even if they were already receiving it without their knowledge.[i] When the volunteers in one of her studies were told they had stopped receiving analgesia they felt more pain, even when the drug was still flowing into their bodies. Anxiety or feelings of being threatened can increase pain, while regaining control (such as giving patients their own drug pump) can reduce it.

One of Tracey’s passions is to help those running clinical trials to see that giving a patient a placebo is not the same as giving them nothing. The fact that many new drugs don’t do much better that the placebo effect is not terrible, because the body’s own painkillers are very strong. This is not a suggestion that doctors should go back to prescribing white tablets in unlabelled bottles. I’m sure there are more sophisticated ways to put this research into practice, but it’s good to know that even a parent’s ‘kiss it better’ approach is actually very powerful.

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By Gentile da Fabriano [Public domain], via Wikimedia Commons
For people with a religious faith, such as the Roman Catholics that Tracey studied a number of years ago, focusing on a meaningful picture (the Virgin Mary) can help them feel less pain. The brain state of these volunteers showed that the effect was different to a placebo, and that their beliefs were actually modulating their perception of pain. It turns out that our beliefs, whether learned from education, upbringing or religion, can also affect the way we feel pain.

This is only the beginning of developing a clearer understanding of pain, but it promises much in terms of improving medicine, and also helping us to understand ourselves and our beliefs. As a Christian myself, I believe that the effects of my prayers are more than a self-help method. It will be interesting to see the results if anyone chooses to continue Tracey’s work on prayer and pain.

[i] This was in a research study with consenting volunteers.

RuthBancewicz
Photo credit: Nigel Bovey

Ruth Bancewicz is a Senior Research Associate at The Faraday Institute for Science and Religion, where she works on the positive interaction between science and faith. After studying Genetics at Aberdeen University, she completed a PhD at Edinburgh University, based at the MRC Human Genetics Unit. She spent two years as a part-time postdoctoral researcher at the Wellcome Trust Centre for Cell Biology at Edinburgh University, while also working as the Development Officer for Christians in Science. Ruth then moved to The Faraday Institute to develop the Test of FAITH resources, the first of which were launched in 2009. Ruth is a trustee of Christians in Science and on the advisory council of BioLogos.

4 thoughts on “The Problem of Pain: Brain imaging and religion

  1. David Thomson December 3, 2015 / 11:09 am

    Reblogged this on Bishop's Blog and commented:
    Another interesting post from Ruth’s site.

    Like

  2. Anne Littlefair December 3, 2015 / 12:45 pm

    I found this of great interest, as I have a chronic neurological condition called Trigeminal Neuralgia, which causes severe facial pain. I’ve had this condition for the past twenty years, so have a vested interested in issues relating to pain! As a Christian, I’m fascinated by the mention of gaining pain relief by gazing upon religious images. In today’s secular world, I have not found much information or discussion of TN, or any neuropathic pain, concerning religious belief.

    Bless you for passing this on, beloved Bishop,
    Anne

    Like

  3. Richard Hosking December 6, 2015 / 10:27 pm

    Hi Ruth,

    Great stuff from Irene! Did she mention the origin of the term ’placebo’ – the idea apparently comes from one of St Jerome’s translations of Psalm 116:9 (“Placebo Domino / I will please the Lord …”).*

    A BBC science documentary covered the placebo effect recently.** One of the amazing findings was short-term symptom relief in patients with Parkinson’s disease (29:19-36:10), where placebo led to actual dopamine release, as demonstrated on brain scans. (This might be one of the general ways in which they work).***

    The program also included a chap who had a wisdom tooth removed under hypnosis without any anaesthesia or pain relief – he transcended dental medication! The astonished look on the face of the dental nurse during the procedure was priceless (46:00-52:48, 51:53).**

    ______

    *Jacobs, B. (2000) ‘Biblical origins of placebo.’ Journal of the Royal Society of Medicine 93(4):213–214.
    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1297986/pdf/10844895.pdf

    **BBC Horizon ‘The Power of the Placebo’ 2013-2014

    ***Colagiuri B. et al (2015) ‘The placebo effect: From concepts to genes.’ Neuroscience 307: 171-190.
    http://www.ncbi.nlm.nih.gov/pubmed/26272535

    Like

    • Ruth M. Bancewicz December 7, 2015 / 1:09 pm

      Thanks for that Richard. She did talk about the origins of the word ‘placebo’, and said that it was used to describe fake mourners at funerals.

      Like

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